Erbb3^tm1Squ
Targeted Allele Detail

Summary

• Symbol: Erbb3^tm1Squ
• Name: erb-b2 receptor tyrosine kinase 3; targeted mutation 1, Shimian Qu
• MGI ID: MGI:3690339
• Synonyms: ErbB3^fl, ErbB3^GIAS
• Gene: Erbb3 Location: Chr10:128403392-128425504 bp, - strand Genetic Position: Chr10, 77.1 cM
• Alliance: Erbb3^tm1Squ page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114524
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A IRES-GFP was inserted into intron 1 in reverse orientation and flanked by loxP sites in the opposite orientation. The cassette contained a splice acceptor sequence and a polyA signal. (J:114524)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb3 Mutation: 48 strains or lines available

References

• Original: J:114524 Qu S, et al., Gene targeting of ErbB3 using a Cre-mediated unidirectional DNA inversion strategy. Genesis. 2006 Oct;44(10):477-86
• All: 9 reference(s)