Fkbp4^tm1Shou
Targeted Allele Detail

Summary

• Symbol: Fkbp4^tm1Shou
• Name: FK506 binding protein 4; targeted mutation 1, Weinian Shou
• MGI ID: MGI:3690438
• Synonyms: Fkbp52^-
• Gene: Fkbp4 Location: Chr6:128407066-128415619 bp, - strand Genetic Position: Chr6, 63.0 cM
• Alliance: Fkbp4^tm1Shou page

Abnormal male reproductive anatomy in Fkbp4^tm1Shou/Fkbp4^tm1Shou mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114715
• Parent Cell Line: CCE916 (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-5 were replaced with a PGK-neo cassette. Northern and Western blot confirmed that the expression was absent in mutant mice. (J:114715)

Disease models

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fkbp4 Mutation: 32 strains or lines available

References

• Original: J:114715 Yang Z, et al., FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor a isoform. Mol Endocrinol. 2006 Nov;20(11):2682-94
• All: 3 reference(s)