Taldo1^tm1Perl
Targeted Allele Detail

Summary

• Symbol: Taldo1^tm1Perl
• Name: transaldolase 1; targeted mutation 1, Andras Perl
• MGI ID: MGI:3690444
• Synonyms: TAL^-
• Gene: Taldo1 Location: Chr7:140972112-140982881 bp, + strand Genetic Position: Chr7, 86.73 cM, cytoband F3-F4
• Alliance: Taldo1^tm1Perl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114691
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced sequence spanning from exon 4 to intron 4, encoding amino acids 138-153. Western blot confirmed that wild-type protein was not detected in mutants. (J:114691)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Taldo1 Mutation: 11 strains or lines available

References

• Original: J:114691 Perl A, et al., Transaldolase is essential for maintenance of the mitochondrial transmembrane potential and fertility of spermatozoa. Proc Natl Acad Sci U S A. 2006 Oct 3;103(40):14813-8
• All: 4 reference(s)