Prop1^tm1Rsd
Targeted Allele Detail

Summary

• Symbol: Prop1^tm1Rsd
• Name: paired like homeodomain factor 1; targeted mutation 1, Michael G Rosenfeld
• MGI ID: MGI:3690463
• Synonyms: Prop1^-
• Gene: Prop1 Location: Chr11:50841633-50844584 bp, - strand Genetic Position: Chr11, 30.95 cM
• Alliance: Prop1^tm1Rsd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114817
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: The entire locus beyond the first 8 amino acids of coding sequence was replaced by a lacZ-neo. Absence of protein was demonstrated by immunostaining. (J:114817)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Prop1 Mutation: 15 strains or lines available

References

• Original: J:114817 Olson LE, et al., Homeodomain-mediated beta-catenin-dependent switching events dictate cell-lineage determination. Cell. 2006 May 5;125(3):593-605
• All: 1 reference(s)