Ret^tm13Jmi
Targeted Allele Detail

Summary

• Symbol: Ret^tm13Jmi
• Name: ret proto-oncogene; targeted mutation 13, Jeffrey Milbrandt
• MGI ID: MGI:3690534
• Synonyms: Ret^RETfloxEGFP, Ret^tm13(RET)Jmi
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm13Jmi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114682
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A loxP site and the human RET9 sequence was inserted with a floxEGFPfrt-neo-frt cassette. The neo was removed by FLP mediated recombination. This allele allows EGFP expression upon the cre mediated deletion of floxed RET9 cDNA from exon 1. (J:114682)

Expression

In Mice Carrying this Mutation:

8 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 54 strains or lines available

References

• Original: J:114682 Jain S, et al., RET is dispensable for maintenance of midbrain dopaminergic neurons in adult mice. J Neurosci. 2006 Oct 25;26(43):11230-8
• All: 13 reference(s)