Igkc^tm1(IGKC)Mnz
Targeted Allele Detail

Summary

• Symbol: Igkc^tm1(IGKC)Mnz
• Name: immunoglobulin kappa constant; targeted mutation 1, Michel C Nussenzweig
• MGI ID: MGI:3690646
• Synonyms: hCkappa, Igkappa^h
• Gene: Igkc Location: Chr6:70703419-70703738 bp, + strand Genetic Position: Chr6, 32.04 cM, cytoband C
• Alliance: Igkc^tm1(IGKC)Mnz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115079
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Humanized sequence, Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: The mouse immunoglobulin kappa chain, constant region was replaced with the human IGKC coding sequence. A floxed neo selection cassette was subsequently removed from properly targeted mice by cre excision. (J:115079)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Igkc Mutation: 9 strains or lines available

References

• Original: J:115079 Casellas R, et al., Contribution of receptor editing to the antibody repertoire. Science. 2001 Feb 23;291(5508):1541-4
• All: 13 reference(s)