Tg(KRT5-Stat3*A661C*N663C)1Jdg
Transgene Detail

Summary

• Symbol: Tg(KRT5-Stat3*A661C*N663C)1Jdg
• Name: transgene insertion 1, John DiGiovanni
• MGI ID: MGI:3690971
• Synonyms: K5.Stat3C
• Transgene: Tg(KRT5-Stat3*A661C*N663C)1Jdg Location: unknown
• Alliance: Tg(KRT5-Stat3*A661C*N663C)1Jdg page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(KRT5-Stat3*A661C*N663C)1Jdg expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Stat3 (MGI:103038)	Transgene codes for a protein with alanine to cysteine and asparagine to cysteine mutations.

• Tg(KRT5-Stat3*A661C*N663C)1Jdg expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  cattle	KRT5 (281268)

• Mutation details: A Stat3 cDNA coding for A661C and N663C substitutions was place under the control of the keratinocyte-specific bovine KRT5 promoter. No line information provided. (J:95458)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:95458 Sano S, et al., Stat3 links activated keratinocytes and immunocytes required for development of psoriasis in a novel transgenic mouse model. Nat Med. 2005 Jan;11(1):43-49
• All: 13 reference(s)