Adgrl1^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Adgrl1^tm1Sud
• Name: adhesion G protein-coupled receptor L1; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:3691022
• Gene: Adgrl1 Location: Chr8:84626734-84668583 bp, + strand Genetic Position: Chr8, 40.22 cM
• Alliance: Adgrl1^tm1Sud page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115214
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2, which encodes amino acids 24-95, and some flanking intronic DNA have been replaced by a neomycin resistance cassette, generating a translational reading-frame shift. Immunoblot analysis with antibodies against the N-terminal, extracellular part of the protein demonstrated its absence in synoptosomes of homozygous mutant mice. (J:115214)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Adgrl1 Mutation: 61 strains or lines available

References

• Original: J:115214 Tobaben S, et al., Genetic analysis of alpha-latrotoxin receptors reveals functional interdependence of CIRL/latrophilin 1 and neurexin 1 alpha. J Biol Chem. 2002 Feb 22;277(8):6359-65
• All: 1 reference(s)