Polh^tm2Fmh
Targeted Allele Detail

Summary

• Symbol: Polh^tm2Fmh
• Name: polymerase (DNA directed), eta (RAD 30 related); targeted mutation 2, Fumio Hanaoka
• MGI ID: MGI:3691063
• Synonyms: Polh^-, Polh³Han, Polh^tm3Han
• Gene: Polh Location: Chr17:46482281-46513567 bp, - strand Genetic Position: Chr17, 22.9 cM, cytoband C
• Alliance: Polh^tm2Fmh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115000
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• A targeting vector was inserted into exon 8, resulting in the production of a truncated protein. (J:115000)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Polh Mutation: 38 strains or lines available

References

• Original: J:115000 Ohkumo T, et al., UV-B radiation induces epithelial tumors in mice lacking DNA polymerase eta and mesenchymal tumors in mice deficient for DNA polymerase iota. Mol Cell Biol. 2006 Oct;26(20):7696-706
• All: 6 reference(s)