Ssr1^{Gt(ble-lacZl)16Brr}
Gene trapped Allele Detail

Summary

• Symbol: Ssr1^{Gt(ble-lacZl)16Brr}
• Name: signal sequence receptor, alpha; gene trap 16, Jacqueline Barra
• MGI ID: MGI:3691069
• Gene: Ssr1 Location: Chr13:38155377-38178184 bp, - strand Genetic Position: Chr13, 17.86 cM
• Alliance: Ssr1^{Gt(ble-lacZl)16Brr} page

Mutation origin

• Mutant Cell Line: TL5
• Germline Transmission: Earliest citation of germline transmission: J:115006
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: A gene trap vector inserted into intron 7, resulting in the removal of the eighth exon and the 3' noncoding region. A fusion protein containing a truncated Ssr1, the phleomycin resistance gene and lacZ was expressed. (J:36630, J:115006)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ssr1 Mutation: 19 strains or lines available

References

• Original: J:115006 Mesbah K, et al., Mutation in the Trapalpha/Ssr1 gene, encoding translocon-associated protein alpha, results in outflow tract morphogenetic defects. Mol Cell Biol. 2006 Oct;26(20):7760-71
• All: 2 reference(s)