Gabra4^tm1.1Geh
Targeted Allele Detail

Summary

• Symbol: Gabra4^tm1.1Geh
• Name: gamma-aminobutyric acid type A receptor subunit alpha 4; targeted mutation 1.1, Gregg E Homanics
• MGI ID: MGI:3691194
• Synonyms: alpha4 KO, f, GABARalpha4
• Gene: Gabra4 Location: Chr5:71727092-71815651 bp, - strand Genetic Position: Chr5, 38.08 cM
• Alliance: Gabra4^tm1.1Geh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115154
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 3 was removed via cre mediated recombination. Absence of protein was demonstrated in hippocampus, thalamus and cortex by Western blot analysis. (J:115154)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gabra4 Mutation: 43 strains or lines available

References

• Original: J:115154 Chandra D, et al., GABAA receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15230-5
• All: 16 reference(s)