Meltf^tm1Drrn
Targeted Allele Detail

Summary

• Symbol: Meltf^tm1Drrn
• Name: melanotransferrin; targeted mutation 1, Des R Richardson
• MGI ID: MGI:3691276
• Synonyms: MTf^-
• Gene: Meltf Location: Chr16:31697628-31717838 bp, + strand Genetic Position: Chr16, 22.4 cM, cytoband B3
• Alliance: Meltf^tm1Drrn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115256
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exons 2-4 were replaced with a floxed neo gene and exon 1 was reversed. The neo was subsequently removed from the locus via cre-mediated recombination. Western blot failed to detect protein in mutant testis and intestine. (J:115256)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Meltf Mutation: 46 strains or lines available

References

• Original: J:115256 Sekyere EO, et al., Role of melanotransferrin in iron metabolism: studies using targeted gene disruption in vivo. Blood. 2006 Apr 1;107(7):2599-601
• All: 3 reference(s)