Tg(Gnrh1-cre)1Dlc
Transgene Detail

Summary

• Symbol: Tg(Gnrh1-cre)1Dlc
• Name: transgene insertion 1, Catherine Dulac
• MGI ID: MGI:3691288
• Synonyms: LHRH::Cre
• Transgene: Tg(Gnrh1-cre)1Dlc Location: unknown
• Alliance: Tg(Gnrh1-cre)1Dlc page

Transgene origin

• Strain of Origin: (C57BL/6 x CBA)F1

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Gnrh1-cre)1Dlc expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Gnrh1 (MGI:95789)

• Mutation details: A cre-containing cassette including a nuclear localization signal and a polyadenylation sequence was inserted into the start codon of the LHRH gene by homologous recombination of the BAC, RP23-22J8 which includes 137 kb of 5' upstream and 73 kb downstream sequences around the LHRH coding sequence of the BAC. The modified BAC was then used to create transgenic mice. (J:115190)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Gnrh1 (mouse) Summary of all recombinase alleles driven by Gnrh1. Comparative matrix view of recombinase activities Alliance mouse Gnrh1 gene page

Expression

In Mice Carrying this Mutation:

15 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:115190 Yoon H, et al., Olfactory inputs to hypothalamic neurons controlling reproduction and fertility. Cell. 2005 Nov 18;123(4):669-82
• All: 36 reference(s)