Pik3ca^tm1.1Jjz
Targeted Allele Detail

Summary

• Symbol: Pik3ca^tm1.1Jjz
• Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1.1, Jean J Zhao
• MGI ID: MGI:3691485
• Synonyms: p110a ^-
• Gene: Pik3ca Location: Chr3:32451203-32520256 bp, + strand Genetic Position: Chr3, 15.7 cM, cytoband B
• Alliance: Pik3ca^tm1.1Jjz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115274
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Exon 1 was removed via transient expression of cre recombinase. Absence of the full length or any truncated form of the p110a isoform was confirmed by Western blot of MEFs. (J:115274)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pik3ca Mutation: 66 strains or lines available

References

• Original: J:115274 Zhao JJ, et al., The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16296-300
• All: 5 reference(s)