Tg(APOE-PCSK9)1Jdh
Transgene Detail

Summary

• Symbol: Tg(APOE-PCSK9)1Jdh
• Name: transgene insertion 1, Jay D Horton
• MGI ID: MGI:3691618
• Synonyms: TgPCSK9
• Transgene: Tg(APOE-PCSK9)1Jdh Location: unknown
• Alliance: Tg(APOE-PCSK9)1Jdh page

Transgene origin

• Strain of Origin: C57BL/6Cr

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(APOE-PCSK9)1Jdh expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PCSK9 (255738)

  Pcsk9

  (MGI:2140260)

• Mutation details: cDNA encoding human PCSK9 was inserted into a pLIv-11 vector containing the constitutive human apoE promoter and its hepatic control region. The linearized construct was injected into fertilized oocytes. (J:114949)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:114949 Lagace TA, et al., Secreted PCSK9 decreases the number of LDL receptors in hepatocytes and inlivers of parabiotic mice. J Clin Invest. 2006 Nov;116(11):2995-3005
• All: 4 reference(s)