Tdrd1^tm1Chum
Targeted Allele Detail

Summary

• Symbol: Tdrd1^tm1Chum
• Name: tudor domain containing 1; targeted mutation 1, Shinichiro Chuma
• MGI ID: MGI:3691852
• Synonyms: Tdrd1^tm1
• Gene: Tdrd1 Location: Chr19:56814641-56858444 bp, + strand Genetic Position: Chr19, 52.0 cM
• Alliance: Tdrd1^tm1Chum page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115333
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to disrupt the first ATG of transcript variants 1-3 and replace the promoter of variant 4 by the insertion of a neo in the ATG in exon 3. In testes, a truncated Tdrd1 mRNA was detected, but Western blot analysis showed absence of any Tdrd1 protein. (J:115333)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tdrd1 Mutation: 50 strains or lines available

References

• Original: J:115333 Chuma S, et al., Tdrd1/Mtr-1, a tudor-related gene, is essential for male germ-cell differentiation and nuage/germinal granule formation in mice. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15894-9
• All: 6 reference(s)