Slc25a19^tm1Mjl
Targeted Allele Detail

Summary

• Symbol: Slc25a19^tm1Mjl
• Name: solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19; targeted mutation 1, Marjorie J Lindhurst
• MGI ID: MGI:3691853
• Synonyms: Slc25a19^-
• Gene: Slc25a19 Location: Chr11:115505004-115519121 bp, - strand Genetic Position: Chr11, 80.91 cM, cytoband E2
• Alliance: Slc25a19^tm1Mjl page

Examples of Slc25a19^tm1Mjl/⁺ control and Slc25a19^tm1Mjl/Slc25a19^tm1Mjl embryos at E10.5

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115337
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: Exons 4-6 were replaced with a neomycin resistance cassette, causing the deletion of amino acids 97-258 and rendering the protein nonfunctional. (J:115337)

Expression

In Structures Affected by this Mutation:

9 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Slc25a19 Mutation: 40 strains or lines available

References

• Original: J:115337 Lindhurst MJ, et al., Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Proc Natl Acad Sci U S A. 2006 Oct 24;103(43):15927-32
• All: 1 reference(s)