Six2^tm1Gco
Targeted Allele Detail

Summary

• Symbol: Six2^tm1Gco
• Name: sine oculis-related homeobox 2; targeted mutation 1, Guillermo Oliver
• MGI ID: MGI:3691857
• Synonyms: Six2^-
• Gene: Six2 Location: Chr17:85991705-85995702 bp, - strand Genetic Position: Chr17, 55.72 cM
• Alliance: Six2^tm1Gco page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115344
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a PGK-neo cassette. Exon 1 contains the transcriptional initiation site, the Six domain and the homeodomain. (J:115344)

Expression

In Mice Carrying this Mutation:	64 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Six2 Mutation: 16 strains or lines available

References

• Original: J:115344 Self M, et al., Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney. EMBO J. 2006 Nov 1;25(21):5214-28
• All: 11 reference(s)