Khdrbs1^tm1Rchd
Targeted Allele Detail

Summary

• Symbol: Khdrbs1^tm1Rchd
• Name: KH domain containing, RNA binding, signal transduction associated 1; targeted mutation 1, Stephane Richard
• MGI ID: MGI:3692384
• Synonyms: Sam68^-
• Gene: Khdrbs1 Location: Chr4:129596957-129636096 bp, - strand Genetic Position: Chr4, 63.34 cM
• Alliance: Khdrbs1^tm1Rchd page

Histological analysis of undecalcified bone from wild type and Khdrbs1^tm1Rchd/Khdrbs1^tm1Rchd mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115775
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neo cassette in reverse orientation replaced exon 4 and most of exon 5. Western blot confirmed absence of protein in mutants. (J:115775)

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Khdrbs1 Mutation: 33 strains or lines available

References

• Original: J:115775 Richard S, et al., Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PLoS Genet. 2005 Dec;1(6):e74
• All: 25 reference(s)