Bbc3^tm1Gpz
Targeted Allele Detail

Summary

• Symbol: Bbc3^tm1Gpz
• Name: BCL2 binding component 3; targeted mutation 1, Gerard P Zambetti
• MGI ID: MGI:3692386
• Synonyms: Puma^-
• Gene: Bbc3 Location: Chr7:16042318-16052130 bp, + strand Genetic Position: Chr7, 8.85 cM
• Alliance: Bbc3^tm1Gpz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115660
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1-3, which contain the transcription and translation start sites and the entire BH3 domain were replaced by a neo. Western blot and real-time PCR confirmed absence of expression in hematopoietic cells. (J:115660)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bbc3 Mutation: 19 strains or lines available

References

• Original: J:115660 Jeffers JR, et al., Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell. 2003 Oct;4(4):321-8
• All: 33 reference(s)