Rgs9^{tm1.1(cre)Yql}
Targeted Allele Detail

Summary

• Symbol: Rgs9^{tm1.1(cre)Yql}
• Name: regulator of G-protein signaling 9; targeted mutation 1.1, Yuqing Li
• MGI ID: MGI:3692442
• Synonyms: RGS9-cre
• Gene: Rgs9 Location: Chr11:109116181-109188955 bp, - strand Genetic Position: Chr11, 71.86 cM
• Alliance: Rgs9^{tm1.1(cre)Yql} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115299
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Rgs9^{tm1.1(cre)Yql} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Rgs9 (MGI:1338824)

• Mutation details: The targeting construct is designed to insert an internal ribosome entry site (IRES), a coding region for a nuclear-localized cre recombinase sequence, and an SV-40 poly(A) sequence, followed by an FRT-flanked neomycin resistance (neo) cassette, between the translational stop codon and transcriptional termination sequence within exon 19. Flp-mediated recombination removed the FRT-flanked neo cassette. (J:115299)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Rgs9 (mouse) Summary of all recombinase alleles driven by Rgs9. Comparative matrix view of recombinase activities Alliance mouse Rgs9 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Rgs9 Mutation: 35 strains or lines available

References

• Original: J:115299 Dang MT, et al., Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15254-9
• All: 32 reference(s)