Jag1^tm2Grid
Targeted Allele Detail

Summary

• Symbol: Jag1^tm2Grid
• Name: jagged 1; targeted mutation 2, Tom Gridley
• MGI ID: MGI:3692444
• Synonyms: Jag1^flox
• Gene: Jag1 Location: Chr2:136923371-136958440 bp, - strand
• Alliance: Jag1^tm2Grid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115783
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exon 4 was flanked by loxP sites. An FRT-flanked neo was removed from the locus. (J:115783)

Disease models

Expression

In Mice Carrying this Mutation:	25 assay results
In Structures Affected by this Mutation:	19 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Jag1 Mutation: 78 strains or lines available

References

• Original: J:115783 Kiernan AE, et al., The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet. 2006 Jan;2(1):e4
• All: 31 reference(s)