Acadm^tm1Uab
Targeted Allele Detail

Summary

• Symbol: Acadm^tm1Uab
• Name: acyl-Coenzyme A dehydrogenase, medium chain; targeted mutation 1, University of Alabama
• MGI ID: MGI:3692446
• Synonyms: MCAD^-
• Gene: Acadm Location: Chr3:153627994-153650269 bp, - strand Genetic Position: Chr3, 78.77 cM
• Alliance: Acadm^tm1Uab page

Histopathology of wild-type and Acadm^tm1Uab/Acadm^tm1Uab mice.

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115759
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A targeting vector was designed duplicate exons 8-10. Translation of the duplicated exon 8 resullted in the formation of a premature stop codon and therefore the resulting protein lacks the C-terminal domain alpha-helixes. (J:115759)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Acadm Mutation: 39 strains or lines available

References

• Original: J:115759 Tolwani RJ, et al., Medium-chain acyl-CoA dehydrogenase deficiency in gene-targeted mice. PLoS Genet. 2005 Aug;1(2):e23
• All: 5 reference(s)