Sall4^tm1Tre
Targeted Allele Detail

Summary

• Symbol: Sall4^tm1Tre
• Name: spalt like transcription factor 4; targeted mutation 1, Mathias Treier
• MGI ID: MGI:3692447
• Synonyms: Sall4^H2bEGFP
• Gene: Sall4 Location: Chr2:168590252-168609121 bp, - strand Genetic Position: Chr2, 88.99 cM
• Alliance: Sall4^tm1Tre page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115635
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace exon 2, encompassing the sequence for the glutamine repeat as well as the first six zinc finger motifs, with an IRES-Histone2bEGFP cassette. The resulting protein was truncated after amino acid 58. A floxed neo in the vector was removed by cre-mediated recombination. (J:115635)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sall4 Mutation: 145 strains or lines available

References

• Original: J:115635 Elling U, et al., Murine inner cell mass-derived lineages depend on Sall4 function. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16319-24
• All: 1 reference(s)