Map3k12^tm1Shir
Targeted Allele Detail

Summary

• Symbol: Map3k12^tm1Shir
• Name: mitogen-activated protein kinase kinase kinase 12; targeted mutation 1, Syu-ichi Hirai
• MGI ID: MGI:3692456
• Synonyms: Dlk^-
• Gene: Map3k12 Location: Chr15:102406079-102425311 bp, - strand Genetic Position: Chr15, 57.63 cM, cytoband F3
• Alliance: Map3k12^tm1Shir page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115575
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1, 2 and part of exon 3 were replaced by lacZ. No protein was detected in mutant brains by immunoprecipitation and Western blotting. (J:115575)

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Map3k12 Mutation: 39 strains or lines available

References

• Original: J:115575 Hirai S, et al., The c-Jun N-terminal kinase activator dual leucine zipper kinase regulates axon growth and neuronal migration in the developing cerebral cortex. J Neurosci. 2006 Nov 15;26(46):11992-2002
• All: 3 reference(s)