Tnf^tm3Gkl
Targeted Allele Detail

Summary

• Symbol: Tnf^tm3Gkl
• Name: tumor necrosis factor; targeted mutation 3, George Kollias
• MGI ID: MGI:3692522
• Synonyms: TNF^delta1-12, Tnf^tm
• Gene: Tnf Location: Chr17:35418357-35420983 bp, - strand Genetic Position: Chr17, 18.59 cM
• Alliance: Tnf^tm3Gkl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114740
• Parent Cell Line: CCE/EK.CCE (ES Cell)
• Strain of Origin: 129S/SvEv-Gpi1^c

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 724 bp sequence containing the second and third exons was replaced with a mutated 511 bp fragment carrying a deletion of the first twelve amino acids of soluble TNF. The neo was subsequently removed. (J:114740)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnf Mutation: 48 strains or lines available

References

• Original: J:114740 Alexopoulou L, et al., Transmembrane TNF protects mutant mice against intracellular bacterial infections, chronic inflammation and autoimmunity. Eur J Immunol. 2006 Oct;36(10):2768-80
• All: 5 reference(s)