Tg(Sim1-cre)1Lowl
Transgene Detail

Summary

• Symbol: Tg(Sim1-cre)1Lowl
• Name: transgene insertion 1, Bradford B Lowell
• MGI ID: MGI:3692526
• Synonyms: Sim1-Cre, Sim1^Cre
• Transgene: Tg(Sim1-cre)1Lowl Location: unknown
• Alliance: Tg(Sim1-cre)1Lowl page

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Sim1-cre)1Lowl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Sim1

• Mutation details: The cre ATG was inserted via recombineering techniques, into the Sim1 ATG site of a BAC containing 137.1 kb of genomic C57BL/6 Sim1 sequences up to and including exon 8. The inserted cre sequence deleted the first 31 bp of the Sim1 gene. (J:115192)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sim1 (species not specified) Summary of all recombinase alleles driven by Sim1. Comparative matrix view of recombinase activities

Phenotypes

Key:

hm	homozygous	ht	heterozygous	tg	involves transgenes	√	phenotype observed
cn	conditional genotype	cx	complex: > 1 genome feature	ot	other: hemizygous, indeterminate,...	N	normal phenotype

Genotype/
Background:

	Allelic Composition	Genetic Background	Cell Line(s)

	Allelic Composition	Genetic Background	Cell Line(s)
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cn1	Rai1^tm2.1Luo/Rai1^tm2.1Luo Tg(Sim1-cre)1Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
cn2	Rai1^tm2.1Luo/Rai1^+ Tg(Sim1-cre)1Lowl/?	either: (involves: 129S1/Sv * C57BL/6 * FVB) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB)
cn3	Nr3c1^tm1.1Mvc/Nr3c1^+ Tg(Sim1-cre)1Lowl/0	involves: 129 * C57BL/6 * FVB
cn4	Saraf^tm1c(KOMP)Wtsi/Saraf^tm1c(KOMP)Wtsi Tg(Sim1-cre)1Lowl/0	involves: 129 * C57BL/6 * FVB	EPD0613_2_B07
cn5	Nr3c1^tm1.1Mvc/Nr3c1^tm1.1Mvc Tg(Sim1-cre)1Lowl/0	involves: 129 * C57BL/6 * FVB
cn6	Col1a1^tm8(CAG-BDNF)Jae/Col1a1^tm8(CAG-BDNF)Jae Tg(Sim1-cre)1Lowl/0	involves: 129S4/SvJae * C57BL/6 * FVB
cn7	Crh^tm2.1Maj/Crh^tm2.1Maj Tg(Sim1-cre)1Lowl/?	involves: 129S4/SvJae * C57BL/6 * FVB/N
cn8	Mc4r^tm1Lowl/Mc4r^tm1Lowl Tg(Sim1-cre)1Lowl/0	involves: 129S4/SvJae * C57BL/6J * FVB
cn9	Mc4r^tm2Lowl/Mc4r^tm2Lowl Tg(Sim1-cre)1Lowl/0	involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * FVB/N
cn10	Mrap2^tm1.2Maj/Mrap2^tm1.2Maj Tg(Sim1-cre)1Lowl/0	involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB/N

Phenotypes:

Affected Systems	cn1		cn2	cn3	cn4	cn5	cn6	cn7	cn8	cn9	cn10
show or hide all annotated terms Sex:
adipose tissue	√				√					√
adipose tissue phenotype					N
decreased brown adipose tissue amount					√
increased total body fat amount										√
increased body fat mass	√
increased total fat pad weight	√
decreased percent body fat/body weight					√
behavior/neurological	√	√			√			√	√	√
behavior/neurological phenotype		N			√				N
abnormal food intake									√
polyphagia	√									√
decreased anxiety-related response								√
decreased locomotor activity		√
increased locomotor activity					√
endocrine/exocrine glands								√
decreased adrenal gland weight								√
adrenal gland atrophy								√
abnormal adrenal gland secretion								√
growth/size/body	√		√	√	√				√	√	√
growth/size/body region phenotype					N				N
increased body fat mass	√
increased lean body mass	√				√				√
decreased body weight				√	√
increased body weight			√						√
obese	√								√	√	√
increased body length										√
increased susceptibility to weight gain											√
homeostasis/metabolism	√			√	√		N	√	√
homeostasis/metabolism phenotype					N		N
decreased circulating corticosterone level								√
increased circulating corticosterone level				√
decreased circulating adrenocorticotropin level								√
increased circulating adrenocorticotropin level				√
abnormal oxygen consumption									√
decreased oxygen consumption									√
increased cholesterol level	√
increased circulating HDL cholesterol level	√
increased circulating LDL cholesterol level	√
increased circulating VLDL cholesterol level	√
increased triglyceride level	√
increased basal metabolism					√
liver/biliary system					N
liver/biliary system phenotype					N
mortality/aging						√
lethality, complete penetrance						√
nervous system				√			√
abnormal hypothalamus physiology				√			√

View phenotypes and curated references for all genotypes (concatenated display).

Expression

In Mice Carrying this Mutation:

35 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

References

• Original: J:115192 Balthasar N, et al., Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell. 2005 Nov 4;123(3):493-505
• All: 63 reference(s)