Tg(Myh6-Tnnt2)117Lnwd
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnnt2)117Lnwd
• Name: transgene insertion 117, Leslie A Leinwand
• MGI ID: MGI:3692598
• Synonyms: cTnT(trunc)
• Transgene: Tg(Myh6-Tnnt2)117Lnwd Location: unknown
• Alliance: Tg(Myh6-Tnnt2)117Lnwd page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tnnt2)117Lnwd expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnnt2 (MGI:104597)

• Mutation details: This transgene expresses a carboxy-terminal truncated mouse Tnnt2 gene under the control of a rat alpha-myosin heavy chain promoter. The truncation corresponds to a truncation described in familial hypertrophic cardiomyopathy patients in which exons 15 and 16 are missing. This line expresses less than 5% of total Tnnt2 as the mutant transgenic form. (J:48301)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:48301 Tardiff JC, et al., A truncated cardiac troponin T molecule in transgenic mice suggests multiple cellular mechanisms for familial hypertrophic cardiomyopathy. J Clin Invest. 1998 Jun 15;101(12):2800-11
• All: 6 reference(s)