Elovl4^tm1Rayy
Targeted Allele Detail

Summary

• Symbol: Elovl4^tm1Rayy
• Name: ELOVL fatty acid elongase 4; targeted mutation 1, Radha Ayyagari
• MGI ID: MGI:3692750
• Synonyms: Elovl4^del, E_mut^-
• Gene: Elovl4 Location: Chr9:83660745-83688330 bp, - strand Genetic Position: Chr9, 45.6 cM
• Alliance: Elovl4^tm1Rayy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114752
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Intragenic deletion
• Mutation details: A 5 bp deletion was engineered in exon 6. A floxed neo was included in the cassette and subsequently removed via cre expression. Western blot confirmed the presence of mutant protein. (J:114752)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Elovl4 Mutation: 36 strains or lines available

References

• Original: J:114752 Vasireddy V, et al., Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration. Invest Ophthalmol Vis Sci. 2006 Oct;47(10):4558-68
• All: 6 reference(s)