Gpbar1^tm1Gvas
Targeted Allele Detail

Summary

• Symbol: Gpbar1^tm1Gvas
• Name: G protein-coupled bile acid receptor 1; targeted mutation 1, Galya Vassileva
• MGI ID: MGI:3692767
• Synonyms: Gpbar1^-, TGR5^-
• Gene: Gpbar1 Location: Chr1:74317709-74318783 bp, + strand Genetic Position: Chr1, 38.53 cM
• Alliance: Gpbar1^tm1Gvas page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115877
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace the entire coding sequence with a neo cassette. Real-time quantitative PCR failed to detect expression in gall bladders from mutant mice. (J:115877)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gpbar1 Mutation: 30 strains or lines available

References

• Original: J:115877 Vassileva G, et al., Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation. Biochem J. 2006 Sep 15;398(3):423-30
• All: 26 reference(s)