Nkx2-9^tm1Jlck
Targeted Allele Detail

Summary

• Symbol: Nkx2-9^tm1Jlck
• Name: NK2 homeobox 9; targeted mutation 1, Joseph Locker
• MGI ID: MGI:3692933
• Synonyms: Nkx2.8^-
• Gene: Nkx2-9 Location: Chr12:56658174-56660069 bp, - strand Genetic Position: Chr12, 24.47 cM
• Alliance: Nkx2-9^tm1Jlck page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115581
• Parent Cell Line: WW6 (ES Cell)
• Strain of Origin: STOCK 129/Sv and C57BL/6J and SJL

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Part of the 5' UTR, exon 1 and intron 1 were replaced with a lacZ-neo. RT-PCR confirmed expression of lacZ and absence of endogenous transcript in mutant lung and brain. (J:115581)

Expression

In Mice Carrying this Mutation:	101 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nkx2-9 Mutation: 8 strains or lines available

References

• Original: J:115581 Tian J, et al., Loss of Nkx2.8 deregulates progenitor cells in the large airways and leads to dysplasia. Cancer Res. 2006 Nov 1;66(21):10399-407
• All: 3 reference(s)