Boc^tm1Aok
Targeted Allele Detail

Summary

• Symbol: Boc^tm1Aok
• Name: BOC cell adhesion associated, oncogene regulated; targeted mutation 1, Ami Okada
• MGI ID: MGI:3692939
• Synonyms: Boc^-
• Gene: Boc Location: Chr16:44305408-44379233 bp, - strand Genetic Position: Chr16, 28.81 cM, cytoband B5
• Alliance: Boc^tm1Aok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115577
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Homologous recombination was used to insert a gene trap vector encoding a strong splice acceptor site, transmembrane domain and beta-geo followed by an IRES-PLAP upstream of the exon encoding the transmembrane domain. The allele proved to be severely hypomorphic. (J:115577)

Expression

In Mice Carrying this Mutation:

9 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Boc Mutation: 61 strains or lines available

References

• Original: J:115577 Okada A, et al., Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature. 2006 Nov 16;444(7117):369-73
• All: 14 reference(s)