Cdon^tm1Aok
Targeted Allele Detail

Summary

• Symbol: Cdon^tm1Aok
• Name: cell adhesion molecule-related/down-regulated by oncogenes; targeted mutation 1, Ami Okada
• MGI ID: MGI:3692942
• Synonyms: Cdon^-
• Gene: Cdon Location: Chr9:35332836-35418948 bp, + strand Genetic Position: Chr9, 20.24 cM
• Alliance: Cdon^tm1Aok page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115577
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Homologous recombination was used to insert a gene trap vector encoding a strong splice acceptor site, transmembrane domain and beta-geo followed by an IRES-PLAP upstream of the exon encoding the transmembrane domain. The allele proved to be severely hypomorphic. (J:115577)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdon Mutation: 66 strains or lines available

References

• Original: J:115577 Okada A, et al., Boc is a receptor for sonic hedgehog in the guidance of commissural axons. Nature. 2006 Nov 16;444(7117):369-73
• All: 7 reference(s)