Flt1^tm1Gne
Targeted Allele Detail

Summary

• Symbol: Flt1^tm1Gne
• Name: FMS-like tyrosine kinase 1; targeted mutation 1, Genentech
• MGI ID: MGI:3693075
• Synonyms: Flt-1^loxP
• Gene: Flt1 Location: Chr5:147498414-147662821 bp, - strand Genetic Position: Chr5, 87.01 cM, cytoband G
• Alliance: Flt1^tm1Gne page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:114973
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A floxed neo cassette was inserted upstream of exon 1. An additional loxP site was inserted downstream of exon 1. Cre-mediated recombination removed the neo cassette and left exon 1 floxed. (J:193210)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Flt1 Mutation: 76 strains or lines available

References

• Original: J:114973 Ambati BK, et al., Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006 Oct 26;443(7114):993-7
• All: 18 reference(s)