Jag1^tm2.1Grid
Targeted Allele Detail

Summary

• Symbol: Jag1^tm2.1Grid
• Name: jagged 1; targeted mutation 2.1, Tom Gridley
• MGI ID: MGI:3693129
• Synonyms: Jag1^del2
• Gene: Jag1 Location: Chr2:136923371-136958440 bp, - strand
• Alliance: Jag1^tm2.1Grid page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:115783
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Jag1^tm2Grid mice were crossed to Tg(Zp3-cre)93Knw mice. Heterozygous females carrying the transgene were crossed to wild-type males to produce mice heterozygous for Jag1 with exon 4 deleted. (J:115783)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jag1 Mutation: 78 strains or lines available

References

• Original: J:115783 Kiernan AE, et al., The Notch ligand JAG1 is required for sensory progenitor development in the mammalian inner ear. PLoS Genet. 2006 Jan;2(1):e4
• All: 1 reference(s)