Tg(tetO/CMV-KRAS*G12C)9.1Msmi
Transgene Detail

Summary

• Symbol: Tg(tetO/CMV-KRAS*G12C)9.1Msmi
• Name: transgene insertion 9.1, Mark Miller
• MGI ID: MGI:3693226
• Synonyms: Ki-ras^G12C
• Transgene: Tg(tetO/CMV-KRAS*G12C)9.1Msmi Location: unknown
• Alliance: Tg(tetO/CMV-KRAS*G12C)9.1Msmi page

Transgene origin

• Strain of Origin: FVB/NTac

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inducible, Inserted expressed sequence)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO/CMV-KRAS*G12C)9.1Msmi expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KRAS (3845)

  Kras	(MGI:96680)

• Mutation details: A genomic segment including the KRAS^G12C mutation was cloned from the H358 human lung bronchioalveolar cell line and placed under the regulation of a tetracycline-inducible (tetO)/cytomegalovirus (CMV) promoter. Copy number is estimated at 22. (J:102839)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(tetO/CMV-KRAS*G12C)9.1Msmi

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:102839 Floyd HS, et al., Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. Carcinogenesis. 2005 Dec;26(12):2196-206
• All: 5 reference(s)