Tg(Myh6-Tnnt2*R92W)1Jcf
Transgene Detail

Summary

• Symbol: Tg(Myh6-Tnnt2*R92W)1Jcf
• Name: transgene insertion 1, Jil C Tardiff
• MGI ID: MGI:3693250
• Synonyms: R92W
• Transgene: Tg(Myh6-Tnnt2*R92W)1Jcf Location: unknown
• Alliance: Tg(Myh6-Tnnt2*R92W)1Jcf page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-Tnnt2*R92W)1Jcf expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tnnt2 (MGI:104597)	Transgene codes for a protein with an arginine to tryptophan mutation.

• Mutation details: This transgene expresses a mouse Tnnt2 gene, with codon 92 mutated to encode a tryptophan instead of the arginine and an 11-amino acid c-myc epitope added to the 5' end of the coding region, under the control of a rat alpha-myosin heavy chain promoter. This line expresses 50% of the total Tnnt2 as the mutant transgenic form. (J:104369)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:104369 Ertz-Berger BR, et al., Changes in the chemical and dynamic properties of cardiac troponin T cause discrete cardiomyopathies in transgenic mice. Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):18219-24
• All: 8 reference(s)