Tg(ACTA1-PABPN1*A17)1Drub
Transgene Detail

Summary

• Symbol: Tg(ACTA1-PABPN1*A17)1Drub
• Name: transgene insertion 1, David Rubinsztein
• MGI ID: MGI:3693304
• Synonyms: A17-1, A17.1
• Transgene: Tg(ACTA1-PABPN1*A17)1Drub Location: unknown
• Alliance: Tg(ACTA1-PABPN1*A17)1Drub page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(ACTA1-PABPN1*A17)1Drub expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  PABPN1 (8106)

  Pabpn1

  (MGI:1859158)

• Mutation details: The transgene contains the human skeletal actin promoter upstream of a mutant bovine cDNA with a series of CGC codons encoding a 17-amino acid polyalanine tract. (J:115642)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available

Notes

Of two lines descended from founders with this transgenic construct, line A7-1 has a more severe phenotype, correlated with higher transgene expression levels, than line A7-2.

References

• Original: J:115642 Davies JE, et al., Doxycycline attenuates and delays toxicity of the oculopharyngeal muscular dystrophy mutation in transgenic mice. Nat Med. 2005 Jun;11(6):672-7
• All: 11 reference(s)