Kmt2c^tm1.1Jwle
Targeted Allele Detail

Summary

• Symbol: Kmt2c^tm1.1Jwle
• Name: lysine (K)-specific methyltransferase 2C; targeted mutation 1.1, Jae Lee
• MGI ID: MGI:3693319
• Synonyms: Mll3^delta, Mll3^tm1.1Rgr
• Gene: Kmt2c Location: Chr5:25476796-25703781 bp, - strand Genetic Position: Chr5, 12.35 cM
• Alliance: Kmt2c^tm1.1Jwle page

Phenotypes of the Kmt2c^tm1.1Jwle/Kmt2c^tm1.1Jwle mouse

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116064
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A loxP site was inserted into intron 56 and an FRT site flanked neomycin resistance gene cassette followed by a second loxP site was inserted into intron 58. Sequence encoding 61 of the 121 amino acids of the SET domain were thus enclosed within loxP sites. Subsequent Cre-mediated recombination resulted in the loss of exons 57-58, including sequence encoding the RYINHS motif, which contributes to the catalytic core region of the SET domain. (J:116064)

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kmt2c Mutation: 180 strains or lines available

References

• Original: J:116064 Lee S, et al., Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15392-7
• All: 7 reference(s)