Cdc42^tm1Yizh
Targeted Allele Detail

Summary

• Symbol: Cdc42^tm1Yizh
• Name: cell division cycle 42; targeted mutation 1, Yi Zheng
• MGI ID: MGI:3693320
• Synonyms: cdc42^flox, Cdc42^loxP
• Gene: Cdc42 Location: Chr4:137047011-137085007 bp, - strand Genetic Position: Chr4, 69.83 cM
• Alliance: Cdc42^tm1Yizh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116100
• Parent Cell Line: iTL1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The targeting construct introduced a neomycin resistance cassette (neo^r), flanked on each side by a loxP followed by a frt site, upstream of exon 2 and a single loxP site downstream of exon 2. The neo^r was deleted by FLP recombinase, leaving a single frt site in intron 1 and loxP sites flanking exon 2, which contains the translation initiation site. (J:120090)

Expression

In Mice Carrying this Mutation:	32 assay results
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdc42 Mutation: 45 strains or lines available

References

• Original: J:116100 Chen L, et al., Cdc42 deficiency causes Sonic hedgehog-independent holoprosencephaly. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16520-5
• All: 45 reference(s)