Irf6^tm1Mjd
Targeted Allele Detail

Summary

• Symbol: Irf6^tm1Mjd
• Name: interferon regulatory factor 6; targeted mutation 1, Michael J Dixon
• MGI ID: MGI:3693324
• Synonyms: Irf6^R84C
• Gene: Irf6 Location: Chr1:192835419-192854331 bp, + strand Genetic Position: Chr1, 97.6 cM
• Alliance: Irf6^tm1Mjd page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116077
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Humanized sequence)
• Mutation: Nucleotide substitutions
• Mutation details: A vector was designed to insert the R84C mutation into exon 3. A neo included in the vector was removed via transient cre expression. (J:116077)

Disease models

Expression

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irf6 Mutation: 26 strains or lines available

References

• Original: J:116077 Richardson RJ, et al., Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. Nat Genet. 2006 Nov;38(11):1329-34
• All: 9 reference(s)