Crtap^tm1Brle
Targeted Allele Detail

Summary

• Symbol: Crtap^tm1Brle
• Name: cartilage associated protein; targeted mutation 1, Brendan Lee
• MGI ID: MGI:3693334
• Synonyms: Crtap^-
• Gene: Crtap Location: Chr9:114204204-114219743 bp, - strand Genetic Position: Chr9, 64.39 cM, cytoband F3-F4
• Alliance: Crtap^tm1Brle page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116096
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced part of exon 1 and all of exon 2. Absence of transcript was confirmed by Northern blot and RT-PCR analyses. (J:116096)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Crtap Mutation: 20 strains or lines available

References

• Original: J:116096 Morello R, et al., CRTAP is required for prolyl 3- hydroxylation and mutations cause recessive osteogenesis imperfecta. Cell. 2006 Oct 20;127(2):291-304
• All: 6 reference(s)