Cask^tm1Sud
Targeted Allele Detail

Summary

• Symbol: Cask^tm1Sud
• Name: calcium/calmodulin dependent serine protein kinase; targeted mutation 1, Thomas C Sudhof
• MGI ID: MGI:3693354
• Synonyms: CASK knockin
• Gene: Cask Location: ChrX:13383319-13713020 bp, - strand Genetic Position: ChrX, 8.43 cM
• Alliance: Cask^tm1Sud page

Cleft palate in Cask^tm1Sud/Cask^tm1.1Sud Tg(Prm-cre)580g/0 mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:117978
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: The first coding exon of the Cask gene is flanked by loxP sites and a neomycin cassette is inserted into the intron adjacent to the floxed intron. The resulting allele is a hypermorph with Cask expression decreased by ~66%. (J:117978)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cask Mutation: 14 strains or lines available

References

• Original: J:117978 Atasoy D, et al., Deletion of CASK in mice is lethal and impairs synaptic function. Proc Natl Acad Sci U S A. 2007 Feb 13;104(7):2525-30
• All: 6 reference(s)