Hnrnpd^tm1Rjsc
Targeted Allele Detail

Summary

• Symbol: Hnrnpd^tm1Rjsc
• Name: heterogeneous nuclear ribonucleoprotein D; targeted mutation 1, Robert J Schneider
• MGI ID: MGI:3693617
• Synonyms: Auf1^-
• Gene: Hnrnpd Location: Chr5:100103794-100126797 bp, - strand Genetic Position: Chr5, 48.46 cM, cytoband E3
• Alliance: Hnrnpd^tm1Rjsc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116112
• Parent Cell Line: W4 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The 5' sequence of exon 3 was replaced with a neomycin resistance cassette. Immunoblot confirmed absence of protein in mutant spleen, thymus and testicle. (J:116112)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hnrnpd Mutation: 26 strains or lines available

References

• Original: J:116112 Lu JY, et al., Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs. Genes Dev. 2006 Nov 15;20(22):3174-84
• All: 6 reference(s)