Smad4^tm1Rdp
Targeted Allele Detail

Summary

• Symbol: Smad4^tm1Rdp
• Name: SMAD family member 4; targeted mutation 1, Ronald DePinho
• MGI ID: MGI:3693621
• Synonyms: Smad4^L
• Gene: Smad4 Location: Chr18:73772080-73836851 bp, - strand Genetic Position: Chr18, 49.51 cM
• Alliance: Smad4^tm1Rdp page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116130
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S/SvEv

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• LoxP sites were inserted to flank exons 8 and 9. (J:116130)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Smad4^tm1Rdp

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad4 Mutation: 48 strains or lines available

References

• Original: J:116130 Bardeesy N, et al., Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev. 2006 Nov 15;20(22):3130-46
• All: 25 reference(s)