Eps8^tm1Ppdf
Targeted Allele Detail

Summary

• Symbol: Eps8^tm1Ppdf
• Name: epidermal growth factor receptor pathway substrate 8; targeted mutation 1, Pier Paolo Di Fiore
• MGI ID: MGI:3693626
• Synonyms: Eps8^-
• Gene: Eps8 Location: Chr6:137454242-137626262 bp, - strand Genetic Position: Chr6, 66.78 cM
• Alliance: Eps8^tm1Ppdf page

Disorganized stereocilia in Eps8l2^tm1Wma/Eps8l2^tm1Wma Eps8^tm1Ppdf/Eps8^tm1Ppdf mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116237
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• A neomycin resistance cassette replaced one exon and part of a second exon. (J:116237)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Eps8 Mutation: 123 strains or lines available

References

• Original: J:116237 Scita G, et al., EPS8 and E3B1 transduce signals from Ras to Rac. Nature. 1999 Sep 16;401(6750):290-3
• All: 13 reference(s)