Hdac7^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Hdac7^tm1Eno
• Name: histone deacetylase 7; targeted mutation 1, Eric N Olson
• MGI ID: MGI:3693627
• Synonyms: Hdac7^-
• Gene: Hdac7 Location: Chr15:97690545-97742383 bp, - strand Genetic Position: Chr15, 53.79 cM, cytoband F2
• Alliance: Hdac7^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116008
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2-5, including the MEF2 binding domain, were replaced with a promoter-less lacz-neo cassette in frame with exon 2. RT-PCR confirmed absence of transcript from mutant mice. (J:116008)

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac7 Mutation: 49 strains or lines available

References

• Original: J:116008 Chang S, et al., Histone deacetylase 7 maintains vascular integrity by repressing matrix metalloproteinase 10. Cell. 2006 Jul 28;126(2):321-34
• All: 5 reference(s)