Parl^tm1.1Bdes
Targeted Allele Detail

Summary

• Symbol: Parl^tm1.1Bdes
• Name: presenilin associated, rhomboid-like; targeted mutation 1.1, Bart De Strooper
• MGI ID: MGI:3693645
• Synonyms: Parl^-
• Gene: Parl Location: Chr16:20098570-20121090 bp, - strand Genetic Position: Chr16, 12.4 cM
• Alliance: Parl^tm1.1Bdes page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116017
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Cre mediated recombination resulted in the excision of exon 2. (J:116017)

Disease models

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Parl Mutation: 28 strains or lines available

References

• Original: J:116017 Cipolat S, et al., Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling. Cell. 2006 Jul 14;126(1):163-75
• All: 5 reference(s)