Lat2^tm2Wz
Targeted Allele Detail

Summary

• Symbol: Lat2^tm2Wz
• Name: linker for activation of T cells family, member 2; targeted mutation 2, Weiguo Zhang
• MGI ID: MGI:3693652
• Synonyms: Lat2^f
• Gene: Lat2 Location: Chr5:134628876-134643879 bp, - strand Genetic Position: Chr5, 74.7 cM
• Alliance: Lat2^tm2Wz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116157
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank the two exons encoding the transmembrane domain and the palmitoylation sites. (J:116157)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lat2 Mutation: 19 strains or lines available

References

• Original: J:116157 Zhu M, et al., Negative regulation of T cell activation and autoimmunity by the transmembrane adaptor protein LAB. Immunity. 2006 Nov;25(5):757-68
• All: 1 reference(s)