Plagl1^tm1Jour
Targeted Allele Detail

Summary

• Symbol: Plagl1^tm1Jour
• Name: pleiomorphic adenoma gene-like 1; targeted mutation 1, Laurent Journot
• MGI ID: MGI:3693683
• Synonyms: Zac1^-
• Gene: Plagl1 Location: Chr10:12966576-13007438 bp, + strand Genetic Position: Chr10, 4.72 cM
• Alliance: Plagl1^tm1Jour page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:116147
• Parent Cell Line: H1 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was desgned to replace sequence including the ATG and the entire zinc finger domain with a neomycin resistance cassette. Absence of protein in mutant pituitary glands was confirmed by Western blot analysis. (J:116147)

Expression

In Mice Carrying this Mutation:	19 assay results
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Plagl1 Mutation: 32 strains or lines available

References

• Original: J:116147 Varrault A, et al., Zac1 regulates an imprinted gene network critically involved in the control of embryonic growth. Dev Cell. 2006 Nov;11(5):711-22
• All: 6 reference(s)